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[3.6] Hints
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Learn to use the large map. It's a bit annoying and hard to use at first; 
however, once you become accustomed to it, you will not be able to play 
with it off.

Learn to hit combos and always have at least Cyclops or Storm on your team 
to increase the damage and XP bonus of combos. For really insane damage 
bonuses, have both leaders on your team. (This is assuming you are building 
up their Leadership skill, which you should.) To score more combos in 
single player, control an X-Man with a slow-developing power or a power 
that affects multiple enemies (Storm is a good choice as her Lightning does 
both). By the time your character's power hits, your teammates will have 
responded to your call and hit with their own powers.

Use the Danger Room to level your X-Men and collect items. Deliberately 
"fail" the course, and you can re-play it and continue collecting items. 
Once you've cleared a DR mission, it will no longer drop items when 
replayed. Any DR scenario which requires you to execute certain commands 
(such as the Teamwork courses) or protect objects is a good candidate for 
collecting items. It's very easy to fail the course.

Concentrate on maximizing a few key mutant powers and skills rather than 
having lots of half-powered abilities. Consider each X-Man's core strengths 
and pick corresponding powers and skills. Cyclops, for example, doesn't 
really need any levels in Critical Strike.

With a few exceptions, powers that damage a single opponent are stronger 
and more useful than wide area powers. Keep your team and their powers 
focused on a single enemy and take your opponents out one-by-one rather 
than trying to blast them all at once. The main exceptions are Colossus' 
Concussion Slam, Psylocke's Psychic Bolts and Jean Grey's Psychic Shout. 
These are also great powers for hitting combos.

Make sure each X-Man that has a special jumping/flying ability gets it 
built up. The exceptions may be Iceman and Magma. Their slides are not 
quite as useful as flying or double-jumping. They are, however, really cool 
to play with, so you may want to level up one of them at least the first 
time you play the game.

As much as possible, use equipment that aids regeneration of health or 
energy, aids in defense or increases damage. Always use nanofiber armor 
rather than other types of armor. Late in the game (at 30th level and 
above), the best backpack item for every X-Man is the Super Power Enhancer: 
+80 to +100 damage to each mutant attack. This damage is also added to 
mutant-enhances melee attacks; e.g. Emma's Psionic Strike. At 40th level, 
you can obtain Ultra Power Enhancers: +125 to +150 damage to mutant 
attacks. Dishing out that much damage makes your X-Men nearly invulnerable.

Lure enemies to you using a ranged fighter to prevent being mobbed.

Consistently use the L button to keep all X-Men focused on a single enemy 
and increase the chances of scoring a combo.

Always take out the strongest enemy first, then deal with the peons. The 
only exception is when there is some method where the enemy is 
regenerating; in that case, take out the regeneration unit first. Examples: 
Morlock Goths resurrecting their comrades; launchers that keep spitting out 
Sentinels, etc. The exception may be if you want a bit of extra XP, you can 
let the bad guys keep coming and keep taking them down. However, if power-
leveling is your thing, DR scenarios are a better choice.

Always save when you reach an Xtraction point. Use a large memory card and 
rotate between two or three saves. If you find you're in bad trouble in a 
stage, you can always go back one or two stages and try something 
different.