With an array of favorite SNK and Capcom characters, and engaging card-battle gameplay, SNK vs. Capcom: Card Fighters DS infuses the winning formula of the original SNK VS. Capcom: Card Fighters' Clash for NEOGEO Pocket Color with updated graphics, an expanded card library and touch-screen capability. Two single-player campaigns, one SNK and one Capcom, are included, as well as an ad-hoc wireless multiplayer mode.

SNK vs. Capcom: Card Fighters DS was chosen as a May 2007 "Editor's Pick" by Tips & Tricks magazine, and named "Game of the Month" by NewTypeUSA in April 2007. According to Kevin Gifford of NewTypeUSA, "My entire summer of 2000 was spent linking up with people for multi-player card battles - and with Cardfighters DS finally in my sweaty hands, I can feel those days coming back to me once more." Chris Bieniek of Tips & Tricks said SNK vs. Capcom: Card Fighters DS offers "the same kind of long-lasting, engaging gameplay" as the popular NEOGEO Card Fighters game, and Geson Hatchett of Hardcore Gamer Magazine hailed the return of "the card fighting game that claimed dozens of social lives."